induction of shear waves in the tissue via an external vibration
source. The waves are then imaged with a phase-contrast MRI
technique by applying motion-encoding gradients synchronized
to the external motion. Finally, the images are mathematically
inverted to calculate tissue stiffness and generate a stiffness map
(i.e., an elastogram).
This study was designed to investigate age-corrected brain
MRE findings in the following four dementia cohorts: ( 1)
Alzheimer disease, ( 2) dementia with Lewy bodies, ( 3) fronto-temporal dementia, and ( 4) normal pressure hydrocephalus.
MRE can also be use to determine differentiating biomarkers in
dementia subtypes. Researchers reviewed 84 subjects including
46 control patients during a four-year period (March 2012 to
February 2016) and found regional stiffness patterns unique to
each dementing disorder.
Dementia includes conditions such as memory loss, cognitive
impairment, and personality and behavioral changes significant
enough to interfere with the ability to perform daily activities.
With its increasing prevalence in today’s aging society, dementia
is a growing public health priority.
AJR in Brief continued from p. 19
PET Molecular Imaging–
Directed Biopsy: A Review
PET-directed biopsy has an increasing role in the diagnosis and staging of
various diseases. Molecular imaging–
guided biopsy approaches have great
potential to increase the detection rate
and improve the diagnostic accuracy.
Therefore, it can have immediate impacts regarding treatment decisions
and patient management.
In this article, the Atlanta-based researchers summarize the applications of PET molecular–
imaging directed biopsy of a variety of anatomic organs in the
management of various diseases with a focus on cancers. They
conducted a PubMed search in January 2017 using the terms:
“PE T,” “Positron Emission Tomography,” “guided OR guidance,”
“biopsy,” and their combinations in the titles and abstracts.
The literature from the search results was recorded and further selected after reading the abstracts. This review covers
PET-directed biopsy involving nearly all anatomic organs and
tissues in the body.
This work was supported in part by grants from the National
Institutes of Health and developmental funds from the Winship
Cancer Institute of Emory University in Atlanta.n
Continued development of the MRE technique
and future longitudinal studies will be
important to expand medicine’s understanding
of the clinical application of brain MRE for
patients with dementia.—John Huston, III
ARRS FUTURE MEETING DATES
2018 Annual Meeting
April 22–27, 2018
Marriott Wardman Park Hotel
2019 Annual Meeting
May 5–10, 2019
Hawaii Convention Center
2020 Annual Meeting
May 3–8, 2020
Sheraton Grand Chicago
2021 Annual Meeting
April 18–23, 2021
Marriott Marquis San Diego Marina
San Diego, CA
Molecular imaging–guided biopsy approaches
have great potential to increase the detection
rate and improve the diagnostic accuracy for
various diseases.—Baowei Fei